Qwo-Li Driskill, a Cherokee Two-Spirit and queer writer and activist, develops the first book-length articulation of Cherokee Two-Spirit critique in this groundbreaking work of Indigenous queer studies. Drawing on Cherokee oral traditions, historical documents, and contemporary testimonies, Driskill examines how gender and sexuality were understood in Cherokee communities before colonization and how these understandings persisted despite centuries of assault. The book introduces 'asegi,' a Cherokee word meaning 'strange' or 'other,' as a framework for understanding gender and sexual diversity within Cherokee cultural contexts rather than through Western categories. Driskill traces how missionary Christianity and federal Indian policy worked to impose binary gender and heterosexuality on Cherokee people, criminalizing traditional practices and kinship structures. Yet the book also recovers stories of resistance and continuity, demonstrating how Two-Spirit people maintained their identities and roles even under colonial pressure. Combining literary analysis of Cherokee texts with activist praxis, Driskill argues that decolonizing sexuality and gender is essential to Cherokee sovereignty and survival. The book speaks to multiple audiences: Indigenous studies scholars, queer theorists, and Cherokee community members seeking to understand and reclaim traditional ways of being. A powerful intervention in both Native American studies and LGBTQ+ studies that insists on the specificity of tribal traditions rather than pan-Indian generalizations.